ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2015, Vol. 24 ›› Issue (2): 190-194.

• 论文 • 上一篇    下一篇

肾小球微管状免疫球蛋白沉积

  

  • 出版日期:2015-04-28 发布日期:2015-04-29

Immunotactoid glomerulopathy

  • Online:2015-04-28 Published:2015-04-29

摘要:

摘要
55岁男性,临床表现为肾病综合征伴血肌酐升高,肾外有贫血、低补体血症,肾活检组织学改变为肾小球系膜区及内皮下区域大量PAS强阳性物质沉积,免疫病理示多种免疫球蛋白及补体在肾小球广泛沉积,电镜证实沉积物为排列紊乱的中空管状物。最终诊断为免疫管状肾小球病。

关键词: 免疫管状肾小球病, 纤维样肾小球肾炎, 微管状结构, 肾活检

Abstract:

ABSTRACT
55-year-old male presented with nephrotic syndrome, renal dysfunction, anemia and hypocomplementemia for 2 months. Renal biopsy showed strongly PAS-positive in mesangial areas and along GBM.Immunofluerescence indicated glomerular positive staining for IgG, IgA, IgM, C3, κ and λ light chain.Ultrastructral examination showed electron dense deposits in subendothelial regions.On high magnification, the deposits were composed of microtubules with distinct hollow centers and mussy arrangement. His final diagnosis was immunotactoid glomerulopathy.

Key words:  Immunotactoid glomerulopathy, Fibrillary glomerulopathy, microtubular structures, renal biopsy