Abstract:

Abstract: The patients with chronic kidney disease usually have progressive protein-energy wasting, which increases the morbidity and mortality. Most body stores of protein are in skeletal muscle, protein depletion presents itself as loss of muscle mass, or muscle atrophy. The pathogenesis of muscle wasting is very complex, which is usually caused by multifactors. The effective treatment currently used is nutritional supplement, assuring enough calories and protein intake. In addition, regular exercising, correction of acidosis and improvement of inflammation also prevent or treat muscle wasting associated with chronic kidney disease. The use of hormone can improve the storage of protein in short term, but there is no study about the application of the efficiency and safety in long term. The method of inhibiting the catabolic pathways which including ubiquitin - proteasome system and myostatin pathway is still in the research stage. More studies are needed for finding effective treatment to improve the outcome of patients with CKD.