ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2013, Vol. 22 ›› Issue (4): 373-379.

• 论文 • 上一篇    下一篇

维持性血液透析患者他汀类药物降脂治疗

  

  • 出版日期:2013-08-28 发布日期:2013-09-03

Advancement in statin regimens in patients undergoing maintenance hemodialysis

  • Online:2013-08-28 Published:2013-09-03

摘要:

摘  要 脂代谢紊乱是诱发心脑血管事件的重要危险因素。他汀类药物降脂治疗对心脑血管的保护作用已为大量研究所证实。维持性血液透析(MHD)患者往往具有显著的脂代谢异常,且心脑血管病亦是MHD患者的主要死亡原因。他汀类药物能否降低MHD患者心脑血管事件的发生及相关死亡已成为新近的研究热点之一。本文对他汀类药物应用于MHD患者的临床研究进展作一综述。

关键词: 关键词 , 维持性血液透析 , 心血管疾病  , 他汀类药物

Abstract:

ABSTRACT  The patients with maintenance hemodialysis (MHD) are associated with accelerated atherosclerosis and increased morbidity and mortality from cardiovascular disease. MHD patients are characterized by a complex plasma dyslipoproteinemic profile. Statin therapy has been proved to reduce the incidence of cardiovascular events and mortality in diverse patient populations at increased risk. There has been concern about the efficacy and safety of statin in MHD patients. This review will focus on the relevant progresses of statin therapy in patients undergoing MHD treatment.

Key words: Key words , maintenance hemodialysis , cardiovascular disease , statin