关键词: 【关键词】 , 肾移植；心脏死亡器官捐献；急性肾功能衰竭

Abstract:

ABSTRACT    Objectives: To explore the clinical effect of kidney transplantation from DCD donors with acute renal failure (ARF). Methodology: Kidney transplantation from DCD donors with ARF from August 2011 to March 2013 was retrospectively reviewed. All donors were China type III donors (donation after cardiac death of brain death patients). ARF was defined by RIFLE criteria. Results: Thirty kidneys from 15 donors with ARF were transplanted into 29 recipients with one patient received dual kidney transplants. Initial and terminal SCr of these donors were 90.1 ± 35.1μmol/L (52~190μmol/L) and 355.6 ± 153.1μmol/L (182~702μmol/L) respectively. Delayed graft function (DGF) occurred in 8 (27.6%) recipients and all recovered within 4 weeks. With a follow-up of 1~21 months, both patient and kidney graft survival were 100%. Mean one and 12-month glomerular filtration rate were 55.5 ± 10.5 and 60.8 ± 10.6 mL/(min•1.73m2) respectively. Conclusions: Kidneys from DCD donors with ARF have excellent short-term outcomes and may represent another potential method to safely expand the donor pool.

Key words: 【Key words】kidney transplantation, donation after cardiac death, acute renal failure