β-arrestin在血管紧张素Ⅱ信号通路中的作用

肾脏病与透析肾移植杂志 ›› 2013, Vol. 22 ›› Issue (3): 254-257.

β-arrestin在血管紧张素Ⅱ信号通路中的作用

出版日期:2013-06-28 发布日期:2013-07-03

β-arrestin research advancements in AngiotensinⅡ signal pathway

Online:2013-06-28 Published:2013-07-03

摘要/Abstract

摘要：

摘要对Arrestin家族的研究是当今生物学信号转导领域的热点之一。近年对肾素－血管紧张素系统（renin-angiotensin system，RAS）认识有重要突破。血管紧张素Ⅱ 1型受体(AT1R)属于G蛋白偶联受体，当血管紧张素Ⅱ激活1型受体后，其下游除传统的G蛋白信号途径，还有新认识的β-arrestin信号通路，两者相互独立。本综述概括了近年来β-arrestin在血管紧张素Ⅱ信号通路中的研究进展，尤其β-arrestin依赖性信号通路的新进展。

Abstract:

Abstract: Arrestin family has recently drawn much attention in signal transduction research, including RAS （renin-angiotensin-systerm）signaling. It has been found that there are two independent signal pathways following the activation of angiotensinⅡreceptor type 1 (AGT1R) by angiotensinⅡ (AngⅡ)：G-protein signal pathway and β-arrestin signal pathway. This review article summarizes the role of β-arrestin in Ang Ⅱsignal pathway, particularly focusing on β-arrestin signal pathway.

Key words: Key Words：&beta, -arrestin；AngiotensinⅡ；AT1R；

赵莉芹，余晨. β-arrestin在血管紧张素Ⅱ信号通路中的作用[J]. 肾脏病与透析肾移植杂志, 2013, 22(3): 254-257.

Zhao Liqin, Yu Chen. β-arrestin research advancements in AngiotensinⅡ signal pathway[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2013, 22(3): 254-257.

ISSN 1006-298X CN 32-1425/R