血管紧张素转移酶2-血管紧张素(1-7)-Mas轴在肾脏病发病机制中的作用

肾脏病与透析肾移植杂志 ›› 2012, Vol. 21 ›› Issue (5): 466-470.

血管紧张素转移酶2-血管紧张素(1-7)-Mas轴在肾脏病发病机制中的作用

出版日期:2012-10-24 发布日期:2012-10-24

The role of ACE2-Ang-(1-7)-Mas axis in pathogenesis of kidney disease

Online:2012-10-24 Published:2012-10-24

摘要/Abstract

摘要：

摘要：肾素-血管紧张素系统( renin angiotensin system, RAS )的过度兴奋，尤其是肾脏局部RAS高表达对肾脏疾病发生发展起着重要的作用[1]。随着对RAS研究的逐步深入，研究发现，除经典的RAS途径外，还有一条新的RAS途径：血管紧张素转移酶2-血管紧张素-(1-7)- Mas受体轴[ ACE2-Ang(1-7)- Mas axis ]，它和经典RAS相互作用，共同调节着机体内环境稳定和维持肾脏功能正常[2]。本文就ACE2-Ang(1-7)- Mas轴在肾脏生理及疾病中的作用及其机制做一简要的综述。

关键词: 血管紧张素转移酶2, 血管紧张素(1-7), Mas受体, 肾素-血管紧张素系统

Abstract:

Abstract: The renin angiotensin system( RAS) plays an important role in the development of kidney disease. especially high expression in local RAS[1]. Along with the further research of RAS gradually, a new RAS was found besides the classical RAS: Angiotensin Converting-Enzyme 2-Angiotensin-(1-7)-Mas receptor axis (ACE2-Ang (1-7)-Mas axis). Interacted with the classical RAS, they regulate the internal environmental stability and maintain normal renal function [2]. This review will focus on the role of ACE2-Ang (1-7)-Mas axis in the physiology and the pathogenesis of kidney disease.

Key words: angiotensin converting-enzyme 2, -angiotensin-(1-7), Mas receptor, The renin angiotensin system

许成燕，顾勇. 血管紧张素转移酶2-血管紧张素(1-7)-Mas轴在肾脏病发病机制中的作用[J]. 肾脏病与透析肾移植杂志, 2012, 21(5): 466-470.

Chengyan XU, Yong Gu. The role of ACE2-Ang-(1-7)-Mas axis in pathogenesis of kidney disease[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2012, 21(5): 466-470.

ISSN 1006-298X CN 32-1425/R