关键词: 肾损伤分子1 , 中性粒细胞明胶酶相关脂质运载蛋白分子 , 梗阻性肾病 , 肾脏预后 急性肾损伤

Abstract:

ABSTRACT   Objective: To evaluate the value of uKIM-1 and uNGAL of detecting AKI caused by obstructive nephropathy. Following up of changes in renal function, to evaluate the value of uKIM-1 and uNGAL as the prognostic indicators of renal outcome. Methodology：The urinary samples of thirty patients with obstructive nephropathy were collected. The levels of uKIM-1 and uNGAL were measured by ELISA at various time intervals. The risk factors of the renal outcome were evaluated. The patients were followed up for at least one year. Results: The Patients with AKI had higher levers of uKIM-1 and uNGAL. The positive correlations between uKIM-1, uNGAL and serum creatinine were found. The AUCs to detect AKI were 0.943 and 0.900. The patients with non complete renal recovery had higher levers of uKIM-1 at 72h postoperative. The AUCs to detect renal prognosis was 0.912. Sensitivity was 85.7% and specificity was 84.6%. Kaplan–Meier analysis revealed that uKIM-1 at 72h postoperative over 156.00pg/mg.Cr predicted progression of renal function. Conclusion: uKIM-1 and uNGAL had good accuracy for detecting AKI. uKIM-1 at 72h postoperative can help predict the renal outcome of obstructive nephropathy.

Key words: KIM-1  , NGAL  , Obstructive Nephropathy , Prognosis Acute Kidney Injury