关键词: 关键词  , 肾移植 缺血再灌注损伤 炎症 微血管病变

Abstract:

ABSTRACT  Ischemia-reperfusion injury (IRI) has been an inevitable event accompanying kidney transplantation. It has a profound influence on both the early and the late function of a transplanted kidney. Ischemia-reperfusion does not exclusively lead to alterations of epithelial cells but also causes interstitial inflammation and interstitial microvasculopathy. Both inflammation and microvasculopathy are particularly important in terms of post-ischemic kidney repair. Post-ischemic microvasculopathy is characterized by endothelial cell swelling with subsequent microvascular occlusion. Thus, reperfusion is inhibited (no-reflow phenomenon). Such endothelial cell dysfunction offers new therapeutic perspectives in IRI in renal transplantation.

Key words: Key words , renal transplantation , ischemia-reperfusion injury , inflammation microvasculopathy