JAK/STAT通路在肾间质纤维化中的进展

肾脏病与透析肾移植杂志 ›› 2012, Vol. 21 ›› Issue (3): 255-259.

JAK/STAT通路在肾间质纤维化中的进展

出版日期:2012-06-28 发布日期:2012-06-25

Research progress of JAK/STAT signaling in renal interstitial fibrosis

Online:2012-06-28 Published:2012-06-25

摘要/Abstract

摘要：

摘要 JAK/STAT通路是一条由多种细胞因子和生长因子介导的信号转导通路，参与细胞的增殖、分化、凋亡、细胞迁移、免疫调节及炎症等生理过程。研究证实，JAK/STAT通路可积极介导肾间质纤维化中的巨噬细胞、肌成纤维细胞和肾小管上皮细胞的病理性活化及损伤，对肾间质纤维化进程具有重要调控作用。深入研究JAK/STAT通路的作用机制，不仅可以进一步明确肾间质纤维化的炎症通路作用网络，还可以为其肾间质纤维化的干预治疗提供新的作用靶点。

关键词: JAK/STAT通路 , 炎症 , 肾间质纤维化

Abstract:

ABSTRACT JAK/STAT pathway is the principal signaling mechanism for a variety of cytokines and growth factors. JAK activation stimulates cell proliferation, differentiation, apoptosis, migration, immune regulation and inflammation. The recent research has verified that JAK/STAT pathway could regulate progression of tubular-interstitial fibrosis through mediating pathological activation and injury of macrophages, myo-fibroblasts and tubular epithelial cells. Further investigation on the mechanisms of signal transduction by JAK/STAT pathway could help us to better understand the inflammation network in renal fibrosis and provide the new targets for intervention treatment.

Key words: Key words , JAK/STAT pathway , inflammation , renal interstitial fibrosis

靳远萌，陈楠. JAK/STAT通路在肾间质纤维化中的进展[J]. 肾脏病与透析肾移植杂志, 2012, 21(3): 255-259.

JIN Yuan-Meng, CHEN Nan. Research progress of JAK/STAT signaling in renal interstitial fibrosis[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2012, 21(3): 255-259.

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