管型肾病的诊断及治疗

肾脏病与透析肾移植杂志 ›› 2012, Vol. 21 ›› Issue (1): 72-77.

管型肾病的诊断及治疗

出版日期:2012-02-28 发布日期:2012-03-09

Diagnosis and management of cast nephropathy in multiple myeloma

Online:2012-02-28 Published:2012-03-09

摘要/Abstract

摘要：

摘要管型肾病是多发性骨髓瘤（multiple myeloma，MM）患者发生急性肾损伤（acute kidney injury，AKI）的主要原因，也是需早期诊断、及时干预的临床急症之一。本文简述管型肾病的发病机制、诊断及治疗，强调血清游离轻链（serum free light chain，sFLC）检测的重要性，并介绍硼替佐米和高截留量血液透析（high cut-off dialysis，HCO-HD）在其治疗中的作用。

Abstract:

ABSTRACT: Cast nephropathy is the major cause of acute kidney injury in multiple myeloma, which should be treated as a medical emergency with prompt diagnosis and intervention to avoid irreversible renal failure. This article will review the diagnosis and management of cast nephropathy. The importance of serum light chain measurement and mainly introducing bortezomib-based chemotherapy and high cut-off hemodialysis should be emphasized.

Key words: cast nephropahty , serum free light chain , bortezomib , high cut-off dialysis

黄高渊，陈惠萍. 管型肾病的诊断及治疗[J]. 肾脏病与透析肾移植杂志, 2012, 21(1): 72-77.

Huang Gao-Yuan, Chen Hui-ping. Diagnosis and management of cast nephropathy in multiple myeloma[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2012, 21(1): 72-77.

ISSN 1006-298X CN 32-1425/R