关键词: 多发性大动脉炎, 阿达木单抗, 肾功能不全, 高血压

Abstract: A young male patient presented with blurred vision and fatigue.Examination revealed acute hypertension,proteinuria3+,elevated serum creatinine,increased erythrocyte sedimentation rate (ESR) and C⁃reactive protein (CRP),while antibody and complement levels were normal.Symptomatic treatment was ineffective,and the patient developed cerebral infarction with claudication.Further investigations identified persistently elevated inflammatory markers and multiple large artery stenoses,leading to a diagnosis of takayasu arteritis and malignant hypertension.After treatment with glucocorticoids,mycophenolate mofetil combined with adalimumab and antihypertensive therapy,blood pressure stabilized,claudication improved,inflammatory markers normalized,and renal function recovered.