ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2024, Vol. 33 ›› Issue (3): 290-294.DOI: 10.3969/j.issn.1006-298X.2024.03.018

• 临床集锦 • 上一篇    下一篇

药物相关Fanconi综合征

  

  • 出版日期:2024-06-28 发布日期:2024-06-26

Drug-related Fanconi syndrome

  • Online:2024-06-28 Published:2024-06-26

摘要: 25岁男性患者,因“服用中成药近1年,乏力3月,发现尿蛋白、尿糖阳性2月”入院,低钾血症,低尿酸血症,提示近端肾小管功能损害,血清肌酐临界值104 μmol/L,诊断Fanconi综合征。肾活检病理提示,可见灶性小管损伤及炎症细胞浸润,排除过敏、中毒、免疫、肿瘤、遗传等其他因素后,考虑药物相关可能性大,予激素、补钾等治疗后,乏力明显改善,1年后停用激素、补钾药物,肾功能、血钾基本恢复正常。


关键词: Fanconi综合征, 低钾血症, 药物相关

Abstract: A 25-year-old male patient was admitted to the hospital because of “taking processed traditional Chinese medicine for nearly a year,fatigue for three months with positive urine protein and sugar for two months”. He also had hypokalemia and hypouricemia,uggesting proximal renal tubular impairment,obtained an elevated value of creatinine (SCr 104 μmol/L) and diagnosed with Fanconi syndrome. Renal biopsy suggested focal tubular injury and inflammatory cell infiltration. After excluding other factors such as allergy,intoxication,immunity,tumor,and genetics,it was highly considered to be drug related. The patient was treated with prednisone,potassium supplementation and other therapies,with a significant improvement in fatigue. One year later,the patients stopped prednisone and potassium supplementation,and the renal function and blood potassium returned to normal.


Key words: Fanconi syndrome, hypokalemia, drug-related