关键词: 腹膜透析, 体成分, 血清肌酐／胱抑素C比值

Abstract: Ｏｂｊｅｃｔｉｖｅ：To evaluate the feasibility of serum creatinine／cystatin C (SCr／CysC) ratio in the assessment of clinical events in peritoneal dialysis (PD) patients.
Ｍｅｔｈｏｄｏｌｏｇｙ：This was a cross-sectional study. Patients aged 16~65 years with maintained PD treatment were enrolled in this study. Baseline clinical characteristics such as gender, age, smoking, diabetes, blood pressure, body surface area(BSA), body mass index(BMI) were obtained. Serum Cr, CysC were measured by standard laboratory techniques. Body composition was examined with BIA. All patients were examined by transthoracic echocardiography to measure diameter of left ventricle. Left ventriclar mass index (LVMI) and relative wall thickness(RWT) were obtained by calculation. The relations between SCr／CysC ratio with body composition, left ventricular geometry remodeling and clinical events (mortality, technique failure, or rehospitalization)were evaluated by Logistic regression.
Ｒｅｓｕｌｔｓ：A total of 104 PD patients were enrolled in final analysis. The mean age of participants was 46.7 years. Among them, 51 (49％) were males. PD treatment modality was mainly DAPD, and mean PD vintage was 49.3 months. Dialysis adequacy data shown with total (renal+peritoneal) Kt／V was 1.85±0.71. Mean SCr／CysC ratio was 0.86±0.23. Variables with moderate to strong correlations with SCr／CysC ratio were body mass index (BMI), arm muscle circumference (AMC), lean body mass (LBM), intracellular water to total body water ratio (ICW／TBW), residual renal function (rGFR), normalized protein catabolic rate (nPCR), creatinine clearance rate (Ccr), left ventricular mass (LVM), subjective global nutritional assessment (SGA), extracellular water to total body water ratio (ECW／TBW). Logistic regression analyses showed that AMC (OR=0.969,95%CI 0.944~0.995), SCr／CysC (OR=0.116,95%CI 0.031~0.432) ratio, and LVMI (OR=1.067,95%CI 1.035~1.100) was independently factor related with clinical events during two years.
Ｃｏｎｃｌｕｓｉｏｎ：The SCr／CysC ratio is appropriate for evaluating body composition and is associated with the clinical events in PD patients with maintained PD treatment.

Key words: peritoneal dialysis, body composition, serum creatinine／cystatin C ratio