关键词: 新型冠状病毒感染, 腹膜透析, 临床特征, 危险因素

Abstract: Ｏｂｊｅｃｔｉｖｅ：To observe clinical characteristics of peritoneal dialysis (PD) patients infected COVID-19, and risk factors of infection.
Ｍｅｔｈｏｄｏｌｏｇｙ：A cohort of PD patients who were prospectively observed in our center from December, 2022 to January, 2023, and the clinical data and risk factors of COVID-19 were analyzed.
Ｒｅｓｕｌｔｓ：Of 404 patients performing PD in this cohort study, 112 patients (27.7％) experienced COVID-19, 10 patients were suspected of infection, 282 patients(69.8％) had no infection. Among the infected patients, 22 cases(19.6％) were positive for SARS-CoV-2 nucleic acid, 90 cases(80.4％) were positive for SARS-CoV-2 antigen. The most common symptoms were fever (112 cases, 100％), cough (101 cases, 90.2％), sore throat (98 cases, 87.5％), fatigue (97 cases, 86.6％), myalgia (73 cases, 65.2％), headache (69 cases, 61.6％),anorexia (62 cases, 55.4％) and anxiety (60 cases, 53.6％). Five hospitalized patients with novel coronavirus pneumonia had a good recovery and were discharged after treatment,none of the patients died. The indexes of the last follow-up pre-COVID-19 were analyzed, the levels of body mass index(BMI), normalized protein catabolic rate(nPCR), serum albumin, serum pre-albumin, lymphocyte count, vaccination rate and home quarantine rate in the infected group were lower than those in the uninfected group (P<0.05). The levels of C-reactive protein (CRP), high sensitivity CRP and interleukin-6 (IL-6) in the infected group were higher than those in the uninfected group (P<0.05). Logistic regression analysis showed that low BMI, nPCR, lymphocyte count and home quarantine rate, high sensitivity CRP were independent risk factors of COVID-19 in PD patients.
Ｃｏｎｃｌｕｓｉｏｎ：The most common symptoms of PD patients infected COVID-19 were fever, cough, sore throat and fatigue, and the short-term prognosis was good. Low body weight, poor nutritional status, poor immune function and microinflammation were independent risk factors of COVID-19 in PD patients. Home quarantine could prevent COVID-19.

Key words: COVID-19, peritoneal dialysis, clinical characteristics, risk factors