Abstract: Ｏｂｊｅｃｔｉｖｅ：To investigate the prevalence and influencing factors of restless legs syndrome (RLS) in maintenance hemodialysis (MHD) patients.
Ｍｅｔｈｏｄｏｌｏｇｙ：This is a multicenter crosssectional study. From July 2020 to November 2020, MHD patients who met the inclusion criteria covering 6 dialysis centers in different regions of the Pearl River Delta were chosen as subjects, then they were divided into RLS group and nonRLS group according to the diagnostic criteria of International Restless Legs Syndrome Study Group (IRLSSG). Patients general information, clinical baseline data, primary disease and medication were analyzed.
Ｒｅｓｕｌｔｓ：A total of 527 patients were enrolled, of whom 546％ were male, with a median age of 570 (470, 670) years. The prevalence of RLS were 72％, 579％ were male, and the median age was 540 (450, 610) years. Compared with the nonRLS group, the blood phosphorus (P=0005) and predialysis urea nitrogen (P=0008) level in the RLS group were significantly increased, the proportion of hypertensive renal damage as the primary disease (P=0005) and the use of sedatives and hypnotics (P=0002) was also significantly higher. Binary Logistic regression analysis demonstrated that blood phosphorus level (P=0013) and hypertensive renal damage (P=0008) were independent risk factors for RLS in MHD patients.
Ｃｏｎｃｌｕｓｉｏｎ：RLS is an important complication of MHD patients, high blood phosphate levels and hypertensive renal damage may promote the occurrence of it.