Abstract: Ｏｂｊｅｃｔｉｖｅ：To investigate the proportion of double negative (DN)T cells in peripheral blood of patients with lupus nephritis (LN) and its correlation with disease activity and prognosis.
Ｍｅｔｈｏｄｏｌｏｇｙ：A retrospective study was performed on patients with LN from 2010 to 2017.According to the median value of DNT cell proportion (460％), the patients were divided into low proportion group(n=138) and high proportion group(n=137).Clinicopathological characteristics and disease remission after 1 year followup of the two groups were compared.
Ｒｅｓｕｌｔｓ：Of the 275 patients, 43 patients (156％) were male with a median age of 27 (21,37) years. The course of SLE and LN were shorter and the SLEDAI score (P=002) was higher in the high proportion group with higher level of lymphocyte proportion, uric acid, and antiC1q antibody, lower level of complement C3 and complement C4 (P<001). Patients in high proportion group had a lower chronic index(CI) score of renal lesions, globular sclerosis and crescent (P<005), and higher incidence of capillary thrombosis (P<005).The percentage of DNT cells decreased from baseline in remission group (P=0001), but not decrease in nonremission group (P=0954). There was no difference in remission rate between the two groups at 1 year of treatment.
Ｃｏｎｃｌｕｓｉｏｎ：The proportion of DNT cells in peripheral blood of LN patients correlated with disease activity of SLE, and decline of DNT cell ratio after treatment was associated with LN remission.