Ｏｂｊｅｃｔｉｖｅ：The Study delves into the clinical efficacy of Roxadustat for treatment of erythropoietin (EPO) hyporesponsive anemia in hemodialysis (HD) patients.
Ｍｅｔｈｏｄｏｌｏｇｙ：A retrospective analysis was performed on 22 patients who had received HD treatment from May 2020 to February 2021. All patients had EPO hyporesponsive anemia, continued treatment with erythropoietin (EPO) for 3 months at a maximum dose≥300 IU／kg／week, but failed to raise hemoglobin levels above 100 g／L. The changes of hemoglobin and iron metabolism were monitored after conversion to roxadllstat.To observe the efficacy of Roxadustat in the treatment of ESA hyporesponsive anemia.
Ｒｅｓｕｌｔｓ：Twentytwo hemodialysis patients (12 males and 10 females) were enrolled, age was 55±16 years old, dry weight was 627±124 kg and duration of dialysis was 102(38,163) months. Baseline hemoglobin was 811±103 g／L at the mean dose of EPO 12 272±2 979 units therapy per week. 4 patients (182％) had transferrin saturation less than 20％, 8 patients (364％) had serum ferritin less than 200 μg／L, and EPO antibody was all negative.The average dose of Roxadustat was 1064±95 mg. After 1, 2 and 3 months of treatment, hemoglobin increased significantly from baseline to 1020±169 g／L, 1027±168 g／L and 1059±161 g／L, respectively (all P<0001).seventeen patients (772％) had higher hemoglobin than 110g／L.Anemia did not improve in 5 patients (227％), the underlying diseases were systemic lupus erythematosus (n=3) or ANCAassociated vasculitis (n=1), 1 patient with transplanted kidney failure was infected with parvovirus.Compared to baseline,total ironbinding capacity increased (478±145 μmol／L vs 397±99 μmol／L, P=0004), while the serum iron, transferrin saturation and serum ferritin had no significant changes. Creactive protein decreased [36 (15, 56) mg／L vs 59 (24, 93) mg／L, P=0041], and serum potassium increased (521±077 mmol／L vs 472±100 mmol／L, P=0033).
Ｃｏｎｃｌｕｓｉｏｎ：Roxadustat is effective for treatment of ESA hyporesponsivenessrelated anemia in patients undergoing hemodialysis.