Chimeric antigen receptor Tcell  (CART) therapy is a new kind of cellular immunotherapy,which can force T cells to express chimeric antigen receptor by gene editing technology,so as to specifically recognize and kill target cells expressing corresponding antigens and then treat diseases.This therapy has achieved good clinical effect in Bcell acute lymphoblastic leukemia and other hematological tumors,but its application in autoimmune diseases such as systemic lupus erythematosus is still in the early stage of preclinical research.This article mainly reviews the immune mechanism of CART therapy and its research progress in autoimmune diseases,in order to provide new ideas for the clinical treatment of autoimmune diseases.