Abstract:

Vitamin D (VD) is an essential hormone which is functional in adjustment of calcium and phosphorus homeostasis and bone metabolism. Treat hemodialysis patients with VD could exert meaningful effect on upregulating expressing of VD receptor, secondary hyperparathyroidism control and reversion of calcium and phosphorus homeostasis. But inappropriate VD treatment, especially early use and overdose treatment of active VD or its analogue also increases internal load of calcium and phosphorus, and the risk of cardiovascular calcification. So this review is trying to summarize detail recommendations and descriptions of VD treatment in CKD-MBD guidelines from multiple countries, standing on angle of benefit against side effect, wish to offer a handy reference to Chinese real clinical practice.