Abstract:

Exosomes are a class of extracellular vesicles released by cells, with a size range of 40150 nm and a lipid bilayer membrane. Exosomes contain membrane receptor, mRNA and microRNA, and may mediate specific celltocell communication and activate signaling pathways in cells they fuse or interact with. With the deepening of its research in recent years, emerging evidence suggests that exosomes can be used as liquid biopsies and noninvasive biomarkers for early detection, diagnosis, and treatment of patients. However, there is no “gold standard” for the separation and purification of exosomes, which limits the research progress. This paper will review the research progress of exosomes, and the method of exosomes separation and purification in recent years．

Key words: exosomes, renal disease