关键词: 慢性肾脏病, 继发性甲状旁腺功能亢进, 甲状旁腺切除术, 甲状旁腺激素, 无动力性骨病

Abstract: Chronic kidney disease (CKD) patients often suffer from secondary hyperparathyroidism (SHPT), a complication which causes mineral metabolism disorders, bone abnormality and ectopic calcification. Parathyroidectomy (PTX) can reduce mortality in SHPT patients who resistant to conventional internal medical therapy, improve their clinical manifestations and quality of life. However, it has been reported that PTX also might cause low circulating parathyroid hormone (PTH) levels and develop a series of adverse outcomes such as adynamic bone disease (ABD), low turnover bone disease (LTBD), vascular calcification (VC) and higher mortality, etc. Therefore, it has important clinical value to overview the pathogenesis, clinical manifestations, and managements of low PTH levels after PTX in CKD patients. Here we highlights the suggested optimal range of postoperative serum PTH levels, clinical manifestations and effective treatments for low PTH levels after PTX.

Key words: chronic kidney disease, secondary hyperparathyroidism, parathyroidectomy, parathyroid hormoneadynamic bone disease