Abstract:

Abstract Complement comprises approximately 40 serum proteins, glycoproteins that exhibit enzymatic activity. Evidence increasingly indicates that the complement system plays a pivotal role in mediating renal diseases. Although complement components are produced in the liver, in recent years, many studies have shown that extrahepatic tissues, including the kidney, brain, blood vessels, lungs, can synthesize small amounts of complement components. Among extrahepatic tissues, the kidney is one of the main sites of complement synthesis. However, recent evidence also suggested that locally expressed complement proteins are involved in renal injury. This review is mainly focus on the significance of renal locally produced complement in renal diseases.

Key words: Complement, Renal cells, Renal diseases