Abstract:

ABSTRACT A 58-year-old female, was first admitted because of mild proteinuria and microscopic hematuria, normal renal function, with anemia. She was normotensive with normal C3 level and κ:λ ratio. Renal biopsy showed mesangioproliferative glomerulonephritis with isolated C3 deposits. The last five months, she had increased proteinuria and hematuria, renal dysfunction, hypertension, decreased serum C3, anemia, elevated κ:λ ratio, with negative immunofixation electrophoresis, and normal finding in bone marrow biopsy and bone marrow cytomorphologic examinations. A repeat renal biopsy revealed a membranoproliferative glomerulonephritis, immunofluorescence demonstrated glomerular deposits that stained for IgG3 and kappa light chain, and electron microscopy revealed global mesangial and subendothelial electron-dense deposits, rare segmental subepithelial deposits of nonorganized feature. The diagnosis was proliferative glomerulonephritis with monoclonal IgG deposits (IgG3-κ).

Key words: C3 glomerulonephritis, proliferative glomerulonephritis with monoclonal IgG deposits, renal biopsy