Abstract:

ABSTRACT Objective: Renal involvement is an under-recognized complication in non-Hodgkin lymphoma (NHL). The aim of this study is to describe the spectrum of renal lesions in patients with NHL. Methodology: Renal involvements related to NHL were identified retrospectively. The clinical features, laboratory data and renal biopsy findings were assessed for each patient at the time of renal biopsy. Results: Twenty patients diagnosed as NHL, including chronic leukocytic leukemia/small lymphocytic lymphoma (n=8), diffuse large B-cell lymphoma (n=4), T/NK cell lymphoma (n=3), lymphoplasmacytic lymphoma (n=2), cutaneous T cell lymphoma (n=1), mucora-associated lymphoid tissue lymphoma (n=1), and mantle cell lymphoma (n=1). All of them presenting with proteinuria, 5 patients had nephrotic syndrome, and 3 had gross hematuria.and. 14 patients had impaired renal function with a high level of serum creatinine 228±181umol/L, A wide spectrum of renal lesions could be observed in renal pathology, included: (1)Membranoproliferative glomerulonephritis–like pattern in 7; (2)Crescent formation in 4; (3)Minimal-change disease in 6; (4)Intraglomerular large B-cell lymphoma in one; (5)Intracapillary monoclonal IgM deposits in one; (6)Primary diffuse large B-cell lymphoma of kidney in one; (7)Lymphocytic infiltration (positive for the B cell marker CD20) of kidney parenchymawas also observed in 8 patients. During follow-up, 2 patients were lost; 9 died; 2 with normal renal function, and the remaining 7 patients had renal function improved after therapy. Conclusion: Although renal involvement related to NHL is infrequent, a wide spectrum of renal lesions is observed, and correlation with the type of lymphoma. Renal biopsy remains essential for diagnosing the kidney involvement.

Key words: non-Hodgkin’s,  , lymphoma, renal lesion, renal biopsy