Abstract:

ABSTRACT  A 43-year-old man presented with proteinuria, hematuria, hypoalbuminemia, hypertension, renal failure, and serum IgA λ monoclonal component. Bone marrow aspirate revealed 5% plasma cells. Renal biopsy showed nodular glomerulopathy. Immunoflurescence indicated linear staining along GBMs and TBMs and mesangial staining in glomeruli for λ light chains and IgA. Ultrastructral examination observedd the punctuate and “powdery” electron-dense deposits along GBMs and TBMs. The final diagnosis was Light and Heavy Chain Deposition Disease.

Key words: light and heavy chain deposition disease  , monoclonal immunoglobulin deposition disease  , renal biopsy