Abstract:

ABSTRACT   Many exogenous and endogenous stresses damage DNA，such as UV radiation, ionizing radiation, chemical carcinogens, reactive oxygen species (ROS), alkylating agents and more. In response to genetic damages，mammalian cells exhibit complex reactions，including cell cycle arrest，DNA repair, DNA demethylation, cell survival and apoptosis. Gadd45 family plays vital roles in DNA damage responses and is regulated precisely at multiple levels. Gadd45 members are involved in tumor, aging, longevity and age-related diseases.

Key words: Key words: , Gadd45, , DNA damage, , cell cycle regulate, , apoptosis