关键词: 甲状旁腺素, 终末期肾病, 慢性肾脏病矿物质与骨异常, 变异性

Abstract:

ABSTRACT Parathyroid hormone (PTH), secreted by parathyroid glands, is an important index of chronic kidney disease-mineral and bone disorder (CKD-MBD). PTH value have variability due to individual differences, diet, blood sampling time and detection methods. PTH target of End-stage Renal Disease（ESRD） is assumed by fraction risk and mortality. But with the absence of robust evidence by far, the causal relationship between PTH and outcome has not been confirmed. The popular view on reading PTH value is to consider the change trend rather than an isolated detection value to guide the clinical practice, and the comprehensive judgment of PTH value should be combined with other related factors. The range of KDIGO guideline（2009）for ESRD is larger than K/DOQI guideline（2003）, which cause an increase in mean lever of PTH globaly. To detect a regular method and a proposal target of PTH still have a long way to go.

Key words: parathyroid hormone, End-stage Renal Disease, Chronic Kidney Disease –Mineral and Bone Disorder, variability