瞬时受体电位通道蛋白6参与血管紧张素II诱导足细胞损伤的信号传导机制

肾脏病与透析肾移植杂志 ›› 2014, Vol. 23 ›› Issue (5): 458-461.

瞬时受体电位通道蛋白6参与血管紧张素II诱导足细胞损伤的信号传导机制

出版日期:2014-10-28 发布日期:2014-11-03

Study On The Signal Transmission Mechanisms Of TRPC6-mediated And AII -induced Podocyte Injury

Online:2014-10-28 Published:2014-11-03

摘要/Abstract

摘要：

摘要足细胞表达瞬时受体电位通道6(TRPC6)，TRPC家族是一类能通透钙离子的非选择性阳离子通道，近年来一些研究发现TRPC6参与血管紧张素II （Ang II）诱导足细胞损伤的病理生理过程。本文就近年来国内外TRPC6一般特性及参与Ang II诱导足细胞损伤的信号传导机制予以阐述。

关键词: TRPC6, 钙离子, 血管紧张素II, 足细胞损伤；信号传导

Abstract:

ABSTRACT Podocytes express canonical transient receptor potential-6 (TRPC6 ), which is a nonselective, Ca(2+)-permeable, cationic channel. Increasing evidence indicates that TRPC6 is involved in AII-induced podocyte injury through pathological calcium signaling in glomerular pathophysiology. This study summarizes the properties of TRPC6 and the signal transmission mechanisms of TRPC6-mediated and AII -induced podocyte injury.

Key words: TRPC6, Ca2+, Angiotensin II, podocyte injury, transmission mechanisms

蔡佳盈|沈世忠|万建新. 瞬时受体电位通道蛋白6参与血管紧张素II诱导足细胞损伤的信号传导机制[J]. 肾脏病与透析肾移植杂志, 2014, 23(5): 458-461.

CAI Jiaying|SHEN Shizhong|WAN Jianxin. Study On The Signal Transmission Mechanisms Of TRPC6-mediated And AII -induced Podocyte Injury[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2014, 23(5): 458-461.

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