关键词: 缺血修饰白蛋白, 腹膜透析, 左心室心肌质量指数, 左心室肥厚, 射血分数

Abstract:

Abstract Objective：The aim of this study was to investigate the link between ischemia modified albumin (IMA) and structure and function of left ventricle in patients on peritoneal dialysis. Methodology: Eighty two end stage renal disease patients on peritoneal dialysis over 3 months were enrolled in this single center study. 36 patients with high IMA level (IMA>85.56 KU/L) were assigned to high IMA group, the other 46 patients were assigned to normal IMA group. Baseline characteristics, IMA levels and echocardiography results were collected and analyzed. Results: They were 48 males and 34 females) with a mean age of 43.4±12.2 years old. In high IMA group, they had significantly higher left atrial diameter (LAD), left ventricular end-diastolic diameter (LVDd), left ventricular posterior wall thickness (LVPWT), septal thickness (IVST), left ventricular mass index (LVMI), and stroke volume (SV) (P<0.05) compared with those in normal IMA group. In addition, the high IMA patients had significantly lower ejection fraction (P<0.05). The IMA levels were signi?cantly correlated with LVDd、LVPWT、IVST、and LVMI, and negatively with levels of hemoglobin, albumin and ejection fraction (P<0.05). Multiple linear regression analysis revealed that LVMI was the most significant factor affecting serum IMA levels in patients on peritoneal dialysis (B=0.86，P<0.01). Conclusions: High serum IMA levels are closely associated with structure and function of left ventricle in patients on peritoneal dialysis. IMA is possibly involved in occurrence and development of cardiovascular events through oxidative stress pathways.

Key words:  ischemia modified albumin, peritoneal dialysis, left ventricular mass index, left ventricular hypertrophy, ejection fraction