Abstract:

ABSTRACT   IgA nephropathy (IgAN) is a common chronic glomerulonephritis that leads to end-stage renal disease (ESRD). There are a lot of studies on histological classi?cation in recent years. The Oxford classi?cation of IgAN published at 2009 is the newest one. It provides four histopathological indicators which may be associated with kidney disease outcomes. They are the mesangial hypercellularity score (M), endocapillary hypercellularity (E), segmental glomerulosclerosis(S) and tubular atrophy/interstitial fibrosis (T). Though it was a multicenter study, the number of patients in the Oxford classi?cation research was limited, and the classification excluded very mild and very acute cases. Since the classi?cation was published, there have been many studies on whether these pathological features are applicable to predict prognosis. Review the 15 recent validation studies, T has the close relationship with the poor outcome，but the prognostic values of M, E, S are still arguable. Few researches included patients with rapidly progressive disease find cellular or fibrocellular crescents (C) may be a prognostic marker. 2 validation studies have showed that E, C lesions are responsive to immunosuppressive therapy.