ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2013, Vol. 22 ›› Issue (5): 441-448.

• 论文 • 上一篇    下一篇

维持性血液透析患者血清25羟维生素D与心脏结构及功能的关系

  

  • 出版日期:2013-10-28 发布日期:2013-10-28

The study of the association  of plasma 25-hydroxyvitamin D levels and cardiac structure and function

  • Online:2013-10-28 Published:2013-10-28

摘要:

摘要  目的: 分析维持性血液透析患者血清25(OH)D和心脏结构与功能两者间的关系。  方法: 回顾性观察126例在我院肾脏病医学中心进行维持性血液透析的患者,记录一般资料,检测血常规、钙磷、全段甲状旁腺激素以及血清25(OH)D,同时检查心脏彩超。  结果: 126例维持性血液透析患者25(OH)D的均值为40.3±19.8nmol/L,男性、女性分别为42.9±20.2nmol/L、36.7±18.8nmol/L,定义血清25(OH)D浓度<25nmol/L为维生素D严重缺乏,<50nmol/L但≥25nmol/L为维生素D缺乏,<75nmol/L但≥50nmol/L为维生素D不足,≥75nmol/L为维生素D充足,患者例数分别为26例、67例、25例和8例,分别占20.63%、53.18%、19.84%和6.35%。患者左心室质量均值为196±56g,男性、女性分别为207±59g、181±50g(P=0.010),左心室质量指数均值为119±33g/m2,男性、女性分别为120±34g/m2、118±33g/m2。分别以质量指数≥125g/m2、≥110g/m2为男性、女性左心室肥厚的诊断标准,左心室肥厚的患病率为44.44%,男性、女性分别为34.25%、58.49%(P=0.007),按照维生素D严重缺乏、缺乏、不缺乏分层,左心室肥厚分布的差异无统计学意义。55.56%的患者存在心脏瓣膜的钙化,主动脉瓣钙化46.03%,二尖瓣瓣膜钙化27.78%,其中主动脉瓣和二尖瓣瓣膜同时钙化占18.25%,44.44%无瓣膜钙化,按照瓣膜钙化数量分层,血清25(OH)D分布的差异无统计学意义。患者左心室射血分数均值为63.1±4.8%,以射血分数<50%作为左心室收缩性心力衰竭的标准,其患病率为2.38%,按照维生素D水平分层,射血分数分布的差异无统计学意义。患者(94例)左心室舒张功能(E/A)均值为0.83±0.25,以E/A<1作为左心室舒张功能不全的标准,其患病率为86.51%,以E/A比分层,血清25(OH)D分布的差异无统计学意义。  结论: 维持性血液透析患者普遍存在维生素D缺乏和不足、左心室肥厚、心脏瓣膜钙化和左心室舒张功能不全,左心室收缩功能不全的比例低。

关键词: 关键词 , 血液透析 , 25-羟维生素D , 左心室肥厚 , 心脏瓣膜钙化 , 心力衰竭

Abstract:

ABSTRACT  Objective: To study plasma 25-hydroxyvitamin D (25(OH)D) levels, cardiac structure and function, and their relationship in patients with maintenance hemodialysis (MHD).  Methodology: Totally one hundred and six MHD patients in our medical center were enrolled in this study. The patients' gender, age, blood pressure, disease history, dialysis history, and medication were investigated. The blood routine, calcium, phosphate, intact parathyroid hormone (iPTH), and 25(OH)D were tested, and doppler echocardiography were also examined for cardiac structure and function.  Results: The serum 25(OH)D in 126 MHD patients was 40.3±19.8nmol/L, male and females' were 42.9±20.2nmol/L and 36.7±18.8nmol/L, respectively. Based on the definition of vitamin D severe deficiency (<25nmol/L), deficiency (25-50nmol/L), insufficiency (50-75nmol/L), and sufficiency (≥75nmol/L), these patients accounted for 20.63%, 53.18%, 19.84%, and 6.35%, respectively. Left ventricular mass (LVM) was 196±56g, male and females' were 207±59g and 181±50g, respectively (P=0.010). Left ventricular mass index (LVMI) was 119±33g/m2, male and females' were 120±34g/m2 and 118±33g/m2, respectively. The total prevalence of left ventricular hypertrophy (LVH) was 44.4% defined by LVMI ≥125g/m2 in male and ≥110g/m2 in female, the prevalence of female’s was higher than that of male's (58.49% vs 34.25%, P=0.007). The prevalence of cardiac valve calcification (CVC) was 55. 6%, and aortic valve calcification, mitral valve calcification, and both valve calcification was accounted for 44.4%, 27. 8%, and 18.3%, respectively. The left ventricular ejection fraction (LVEF) was 63.1±4.80%, the prevalence of systolic heart failure (LVEF<50%) was 2.38%. The E/A was 0.83±0.25 in 94 patients, the prevalence of diastolic heart failure (E/A<1) was 86.5%.  Conclusion: In MHD patients, the deficiency and insufficiency of vitamin D, left ventricular hypertrophy, cardiac valve calcification, and left ventricular diastolic dysfunction were high prevalence.

Key words: 【key words】 , hemodialysis (HD) , 25-hydroxyvitamin D (25(OH)D) , left ventricular hypertrophy (LVH) , cardiac valve calcification (CVC) , heart failure (HF)