ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2013, Vol. 22 ›› Issue (1): 95-99.

• 论文 • 上一篇    

肝移植术后尿检异常,肾功能不全

  

  • 出版日期:2013-02-28 发布日期:2013-03-19

Chronic kidney disease in post liver transplantation patient

  • Online:2013-02-28 Published:2013-03-19

摘要:

摘要:48岁男性患者,乙肝肝硬化12年。亲体肝移植术后3年,术后采用他克莫司,霉酚酸酯联合激素抗排斥治疗。近1年出现尿检异常伴血清肌酐升高。肾活检示75%的肾小球废弃,肾小管间质病变重,肾动脉狭窄伴透明变性,免疫荧光示IgA与C3在系膜区沉积。诊断考虑肝移植后肾损害。
 

Abstract:

ABSTRACT   A 48-year-old man, who had treated with tacrolimus for three years post orthotopic liver transplant, presented with renal dysfunction and abnormal urinanalysis. Renal biopsy showed 75% of glomerulosclerosis, diffuse interstitial ?brosis with tubular atrophy, and arteriolar hyalinosis. Immunofluerescence showed IgA and C3 deposited in mesangial areas. The final diagnosis of post liver transplantation chronic renal damage was made.

Key words:  Orthotopic liver transplant, Chronic kidney disease, , Calcineurin inhibitor toxicity