Abstract:

Previous studies found that the pathogenesis of a variety of glomerulonephritis were associated with abnormal regulation of the complement system, specifically, with dysregulation of the alternative pathway of the complement system. In recent years, clinicians have observed a group of glomerulonephritis which is characterized by glomerular deposits of C3, with no or only scanty glomerular deposits of immunoglobulin, and which pathogenesis may be related to genetic and acquired complement dysregulation. This group of glomerulonephritis was named C3 glomerulopathy, and was classified according to their clinical presentation and possible pathogenesis. This article summarized this group of glomerulonephritis and the relationship between dysregulation of the complement system and glomerular inflammation.