Abstract:

Diabetic nephropathy (DN) is one of the causes of endstage renal disease. The renal lipid deposition and metabolic disorder is not only with the onset of DN, but also affect the progress of chronic kidney disease. Free fatty acid (FFA) in recent years, more attention paid to the metabolic function of DN, FFA metabolic disorder lead to fat cholesterol gathered enough cells toxicity is DN one of the key factors. A lot of research probes into the mechanism of FFA metabolic abnormalities and changes of sertoli cell function and the role of death. In this paper, the characteristics and its influence to the FFA levels and metabolic abnormalities molecular mechanism of sertoli cell dysfunction will be reviewed.