Abstract:

Abstract: Allopurinol is widely used for the treatment of hyperuricemia and gout, but severe cutaneous adverse reactions still happened to some patients and even is life-threaten. In recent years, many studies have found that there are very strong associations between allopurinol induced severe cutaneous adverse reactions and HLA-B*5801, and some studies also have found that the dose of allopurinol, the status of renal function, the usage of thiazide diuretics and so on may influence the adverse reactions. The test for HLA-B*5801 can prevent the occurrence of allopurinol induced cutaneous adverse reactions before using allopurinol. This article reviews the relationship between HLA-B*5801 and allopurinol.

Key words: allopurinol, cutaneous adverse reaction, HLA-B*5801