Abstract:

Abstract Transcriptomics is an approach to study gene expression change based on RNA level. Currently, there are mainly two technologies used for collecting and analyzing transcriptomic data, i.e., microarray that is based on nucleic acid molecular hybridization, and RNA sequencing (RNA-Seq) based on direct sequencing to identify the RNA molecules. Both of the two technologies have made high throughput gene expression profiling of cells and tissues available, and they have provided insights into the mechanisms of various diseases. Focal segmental glomerulosclerosis (FSGS) is one of the most common causes of steroid resistant nephrotic syndrome (SRNS) and renal failure among adults and children. The pathomechanism of FSGS is still unclear, and further effort is required to understand this disease. There have been several studies in which transcriptomic analysis of FSGS were performed, which have provided some insights into the mechanism of FSGS. This review describes the findings in these studies.

Key words:  primary focal segmental glomerulosclerosis, transcriptome, Microarray, RNA Sequencing