Abstract:

Abstract： Cardiovascular disease is the first important cause of death in chronic kidney disease, especially in hemodialysis, in which vascular calcification (VC) plays a key role in the progression. Vitamin K-dependent protein can inhibit calcification in the arterial, and vitamin K has a vital function as a cofactor. Insufficiency of vitamin K leads to severe VC, while high vitamin K intake resulted in reduced VC significantly. This review is to summarize vitamin K, vascular calcification and its clinical implications.

Key words: chronic kidney disease,  , vitamin K,  , Matrix Gla protein,  , vascular calcification