Abstract:

Abstract      Protein C（PC）is a vitamin K-dependent glycoprotein and circulates in plasma. Activated protein C（APC）is generated when thrombin-thrombomodulin complex activates protein C. Besides its important anticoagulant role, APC exerts multiple functions including anti-inflammatory activities, antiapoptotic activity and protection of endothelial barrier effect. A lot of studies revealed that APC was associated with diverse diseases. This review emphasizes the relationship between APC and diabetic nephropathy.

Key words:  , activated protein C；cytoprotective effects；variant；diabetic nephropathy