Abstract:

Systematic light chain amyloidosis (AL amyloidosis) is the most common of the systemic amyloidosis.There is no treatment standard yet.The choice of treatment mainly depends on the severity of the disease.Immunomodulatory drugs (IMiDs) exert antitumor effect via several mechanism and play a role in the newly diagnosed as well as the relapsed/refractory patients.In this review,we will focuse on the use of the three IMiDs (thalidomide,lenalidomide and pomalidomide) in the treatment of AL amyloidosis.

Key words: immunomodulatory drugs, systematic light chain , amyloidosis, treatment