Abstract:

ABSTRACT   Distal nephron is composed of DCT, CNT, and CD, which plays a critical role in regulating kidney ion transport. The discovery of WNKs and claudins points to the underlying mechanisms that dictate Na+, K+ and Cl- transport in the distal nephron. They should be understood in order to fully comprehend the pathophysiology, manifestations, and treatment of many clinical entities such as hypovolemic shock, congestive heart failure, primary hyperaldosteronism, pseudo-hypoaldosteronism and hypertension et al. Here the underlying molecular mechanisms that dictate Na+, K+ and Cl- handling in the distal nephron is reviewed.

Key words: Distal nephron  , ion   , transport  , regulating mechanism