Abstract:

ABSTRACT Objective：To identify the relationship of arterial stiffness with oxidative stress and micro infalammation state in the middle-age and eldly hemodialysis patients. Methodology: Sixty two cases with maintenance hemodialysis (MHD) were enrolled in this study. Based on the presence or absence of carotid arterial stiffness (CAS), they were divided into MHD+CAS group (n=42) and simply MHD group (n=20). The carotid atherosclerosis parameters β obtained by ultrasound technology was used to assess arterial stiffness. The parameters of albumin (ALB), calcium (Ca), serum phosphorus (P), total cholesterol (TC), high density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TG serological markers ), glucose, creatinine, and C-reactive protein were routinely tested in both of the two groups. The levels of TNF-α, IL-6 and 8-isoprostane F2α were measured by ELISA. Results: （1）In MHD + the CAS group, they were 31 males and 11 females with an age of 45 - 73 years old (57.2 ± 7.80) , and the dialysis duration of 3 - 61 months ( median 34 months). In the MHD group, they were 12 males and 8 females with an age of 47 -76 years old (56.2 ± 8.7), and the dialysis duration of 3-56 months ( median 32 months ).（2）The respect of age, dialysis duration, the levels of DBP , BUN , Cr , TC , TG , HDL , LDL, and Hb have no significant difference between the MHD+CAS group and MHD group. The level of SBP in the MHD +CAS group was higher than that in the MHD group. （3）The level of 8-isoprostane in the MHD+CAS group was higher than that in the MHD group (68.8 ± 45.9 vs 25.6 ± 27.5 pg/ml, P <0.01) respectively. The levels of hs-CRP、TNF-α、and IL-6 in both groups was higher than that of the normal levels, but they have no statistical difference. Conclusion: We demonstrate that there is a micro inflammation state in MHD patients. The inflammatory factor may lead to atherosclerosis, but hypertension and oxidative stress may be more important.

Key words: Key words: hemodialysis arterial stiffness inflammatory cytokines 8-isoprostane F2&alpha