Abstract:

ABSTRACT Objective：To evaluate the effects of low dose of thymoglobulin and ALG-P in the induction therapy for kidney transplant recipients. Methodology: One hundred twenty cases with first kidney transplant were randomly divided into 3 group: low dose of thymoglobulin group (n=44)；ALG-P group（n=36）and control group （n=40）. Follow-up was 1 year. The peripheral T—lymphyote absolute counts, graft function recovery, allergic reaction, the rates of infection and acute rejection, the rates of delayed graft function （DGF）, and the change of leukocytes and platelets were statistically compared among the three groups. Results: The peripheral T-lymphyote absolute counts were decreased more significantly in ALG-P group and low dose of thymoglobulin group, especially CD4+T Lymphocyte, at third, 9th, 1, 3, and 6 month postoperative, were decreased more significantly. Compare with control group, the delayed acute rejection and no acute rejection in one week，the rate of acute rejection and delayed graft function were more lower, graft function recovery were better, the rate of allergic reaction, the decrease of platelets were more significantly，but not leaded to severe consequence. Compare with ALG-P group, in low dose of Thymoglobulin group, the peripheral T-lymphyote absolute counts were decreased more significantly postoperative early (within three months after transplantation), especially CD4+T Lymphocyte, at third、9th、one and three month postoperative were decreased more significantly (P<0.05). The rate of acute rejection and delayed graft function were more lower (P<0.05), graft function recovery was better, the rate of allergic reaction, and the decrease of leukocytes and platelets were no differences between two groups (P>0.05). Conclusions: ALG-P and low dose of Thymoglobulin are effective and safe in induction therapy for kidney transplant recipients which can be the optimal choice for induction therapy. Compare with ALG-P group, low dose of Thymoglobulin group was decreased more significantly the rate of acute rejection and delayed graft function, and graft function recovery was better.