Abstract: The imbalance of intestinal flora can destroy the intestinal barrier function. Pathogenic bacteria and their harmful metabolites move through the intestinal mucosal barrier to the blood, causing chronic inflammation and aggravating kidney damage. The recovery of intestinal microecology is expected to become a new target for the treatment of diabetic kidney disease(DKD). A large number of studies have confirmed that there is intestinal flora imbalance and intestinal barrier damage in DKD, but its specific pathogenesis has not been elucidated. This article reviews the imbalance of intestinal flora, intestinal barrier damage and intervention measures to restore intestinal microecology in DKD. It is expected to provide new ideas for the prevention and treatment of DKD.

Key words: diabetic kidney disease, intestinal flora, bacterial metabolites, intestinal barrier