Abstract: A middle-aged female patient with nephrotic syndrome with renal biopsy indicated that leukocyte cell-derived chemotaxin 2 (LECT2) amyloidosis complicated with stage Ⅱ membranous nephropathy. The symptoms were not well controlled after the symptomatic treatment was supported by irbesartan and hydrochlorothiazide. After being transferred to our hospital, low-dose prednisone was added when other types of amyloidosis nephropathy were excluded by laser microdissection mass spectrometry (LMD-MS). After 24 weeks of follow-up, urinary protein was partially relieved and edema was significantly improved.

Key words: leukocyte cell-derived chemotaxin 2, amyloidosis, membranous nephropathy, laser microdissection and mass spectrometry