Abstract: CD36 is a multifunctional receptor that recognizes ligands such as fatty acids, oxidized low⁃density lipoprotein, advanced oxidation end products, and apoptotic cells. It plays a role in lipid uptake, immune recognition and regulation, inflammatory responses, angiogenesis, cell adhesion, and apoptosis. The expression and intracellular localization of CD36 are regulated by various ligands through transcriptional and post⁃translational modifications. CD36 functions as a critical receptor for immune signaling, fatty acid metabolism, and transport in diverse cells, including macrophages, monocytes, dendritic cells, T cells, and B cells. The close association between metabolic diseases and immune dysregulation has led to the development of immunometabolism, a research field that integrates cellular metabolism and immunology. Due to its multifaceted roles in different immune and non⁃immune cells, CD36 serves as a bridge connecting immunity and metabolism, significantly influencing the immunometabolic status in various diseases, such as diabetic nephropathy, metabolic dysfunction⁃associated steatotic liver disease, atherosclerosis, and cancer.

Key words: font-family:Inter, -apple-system, BlinkMacSystemFont, ", font-size:16px, background-color:#FFFFFF, ">CD36、immune cells、immunometabolism