Abstract: A 25-year-old male patient was admitted to the hospital because of “taking processed traditional Chinese medicine for nearly a year，fatigue for three months with positive urine protein and sugar for two months”. He also had hypokalemia and hypouricemia，uggesting proximal renal tubular impairment，obtained an elevated value of creatinine （SCr 104 μmol／L） and diagnosed with Fanconi syndrome. Renal biopsy suggested focal tubular injury and inflammatory cell infiltration. After excluding other factors such as allergy，intoxication，immunity，tumor，and genetics，it was highly considered to be drug related. The patient was treated with prednisone，potassium supplementation and other therapies，with a significant improvement in fatigue. One year later，the patients stopped prednisone and potassium supplementation，and the renal function and blood potassium returned to normal.

Key words: Fanconi syndrome, hypokalemia, drug-related