Abstract: Diabetic nephropathy (DN) is one of the common microvascular complications of diabetes and the main cause of end-stage kidney injury. DN is an inflammatory and immune injury disease caused by metabolic factors, which is related to metabolic disorders,hemodynamic abnormalities, inflammation and other factors. The cyclin nucleotide adenine nucleotide synthase-interferon gene stimulator (cGAS-STING) pathway is a component of innate immunity. Stimulator of interferon gene (STING) is a kind of endoplasmic reticulum activating protein. It experiences dsDNA sensing (cGAS), intracellular signal transduction (STING, TBK1), immune response activation (IRF3, NF-κB), and participates in innate immune response and inflammatory response. Cgas-sting pathway plays an important role in infection, inflammation and tumor development, but its role in DN remains unclear. This article systematically summarizes the research progress of cGAS signaling pathway in the pathogenesis of DN in recent years.

Key words: diabetic nephropathy, stimulator of interferon gene, immune inflammation