Abstract: A 42yearold male on regular hemodialysis for one month was referred to our hospital because of weakness and shortness of breath for one day. Laboratory tests showed markedly prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT), which failed to be corrected by APTT mixing test, and thrombin time (TT) was normal. Factor V (FV) activity was decreased and the FV inhibitor was detected. Blood coagulation function returned to normal after glucocorticoid therapy. The patient had a good prognosis and was recurrencefree during one year of followup. Acquired factor V deficiency is a rare coagulopathy with a variety of clinical presentations, and has a poor prognosis in patients with chronic disease. Early diagnosis and treatment can improve the prognosis, and clinicians need to be aware of drugassociated complications.

Key words: uremia, hemodialysis, acquired factor V deficiency, acquired factor V inhibitor, glucocorticoid