Abstract: A 34-year-old male presented with massive proteinuria and mild microscopic hematuria seven years after kidney transplantation,treated with immunosuppressive therapy of mycophenolate mofetil, tacrolimus and prednisone. Renal biopsy revealed focal segmental glomerulosclerosis with IgA deposition, and nodular hyaline deposits in the media and adventitia of arterioles.The final diagnosis was allograft IgA nephropathy with calcineurin inhibitor nephrotoxicity.

Key words: renal transplantation, IgA nephropathy, focal segmental glomerulosclerosis, calcineurin inhibitor nephrotoxicity