Abstract: A 40-year-old male patient presented with the underlying disease lipoprotein nephropathy.Five years after renal transplantation,he developed proteinuria, elevated serum creatinine, and high serum apoE, and renal biopsy showed graft lipoprotein nephropathy. Five years after renal transplantation, proteinuria, serum creatinine and ApoE were elevated, and renal biopsy showed graft lipoprotein nephropathy.The mutant type of ApoE gene was P.L162K164del.Patient also carries ANLNR39X gene.Graft lipoprotein nephropathy is considered.After 9 treatment with double plasmoplasty combined with fenofibrate, ApoE levels decreased.However, lipoprotein emboli in the glomerular capillary loops did not disappear after repeated renal biopsy.

Key words: lipoprotein glomerulopathy, apolipoprotein E, renal transplantation, double filtration plasmapheresis